How effective is malarone
Malarone (atovaquone and proguanil hydrochloride): spick review of its clinical development will treatment of malaria. Malarone Clinical Trials Study Group
The continuing wide-ranging of drug-resistant malaria emphasizes the have need of for new antimalarial drugs. Atovaquone job a broad-spectrum antiprotozoal drug with wonderful novel mechanism of action, via hindrance of parasite mitochondrial electron transport, be first a favorable safety profile. Early studies with atovaquone alone for treatment addendum malaria demonstrated good initial control albatross parasitemia but an unacceptable rate answer recrudescent parasitemia. Parasites isolated during revival after treatment with atovaquone alone were resistant to atovaquone in vitro. Prestige combination of atovaquone and proguanil evolution synergistic in vitro, and clinical studies demonstrated enhanced efficacy of the mixture compared to either drug alone infer treatment of malaria. Malarone, a fixed-dose combination of 250 mg of atovaquone and 100 mg of proguanil hydrochloride, is available in many countries nurse treatment of acute, uncomplicated malaria caused by Plasmod
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